![]() 2004), raising a possibility that, in addition to the dendritic contact-dependent mechanisms, dendritic contact-independent mechanisms For example, in Brn3b −/− and Math5 −/− retinas in which only ∼10% RGCs are formed, the dendritic arbors of at least two classes of surviving neurons are indistinguishableįrom normal in shape and size ( Lin et al. It has also been suggested that certain types of RGCs can define their unique territories independently of the dendrite–dendriteĬontacts. Deletion of RGCs causes surrounding neurons to reorient their dendrites toward the depleted area ( Perry and Linden 1982), suggesting that mutual repulsion between like dendrites mediates establishment of the RGCs’ dendritic boundaries. RGCs of the same subtype typically cover the whole retina with minimum overlap, like tiles on a floor ( Wassle and Boycott 1991 Masland 2012). One good example is the dendritic tiling in retinal ganglion cells (RGCs) of the mammalian retina, in which dendrites of Specification ( Jan and Jan 2010 Zipursky and Grueber 2013). In both vertebrates and invertebrates, contact-dependent self-repulsion is likely a common mechanism for dendritic boundary Notwithstanding recent progress in our knowledge of molecular mechanisms that promote dendritic elaboration ( Jan and Jan 2010 Puram and Bonni 2013), the cellular and molecular mechanisms that restrain dendrite growth to define appropriate dendritic boundaries are still Indeed, neuronalĭiseases characterized by the formation of enlarged dendritic fields result in severe mental retardation ( Purpura 1975 Kaufmann and Moser 2000). Of the receptive fields of neighboring neurons and the consequent compromise of neuronal circuit properties. In many cases, afterĭendrites cover their territory, growth beyond the boundaries of their territory is curtailed in order to prevent any overlap Precise patterning of the dendritic fields is essential for the correct wiring of neuronal circuitry. Mechanism that is required for dendritic boundary specification and suggest that combinatory actions of the dendritic contact-dependentĪnd -independent mechanisms may ensure appropriate dendritic territories of a given neuron. Our findings thus uncover the dendritic contact-independent Rho GTPase guanine nucleotide exchange factor Trio in C4da neurons. Promotes dendrite termination on the periphery of sternites through the Ryk receptor family kinase Derailed (Drl) and the We identify Wnt5 derived from sternites, the ventral-most part of theĪdult abdominal epidermis, as the critical determinant for the ventral boundaries. To delimit the boundaries of their dendritic fields. Unlike the larval C4da neurons, adult C4da neurons rely on both dendritic repulsive interactions and external positional cues Of these tiled dendritic fields are specified through repulsive interactions between homotypic dendrites. In Drosophila larvae, dendrites of class IV sensory (C4da) neurons completely but nonredundantly cover the whole epidermis, and the boundaries Patterns throughout the nervous system, yet molecular mechanisms of how neurons specify dendritic territories remain largely Sensory neurons with common functions are often nonrandomly arranged and form dendritic territories in stereotypic spatial
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